IndraLab

Statements

CTNNB1 activates DKK4. 6 / 7
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"However, DKK4, induced by beta-catenin activation, was found to be upregulated and promote invasion and angiogenesis in human colon cancers [XREF_BIBR, XREF_BIBR]."
28666421
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"Furthermore, the relationship between glucose and DKK4 became apparent because stabilization of beta-catenin by inhibiting GSK3beta under normoglycemic condition causes abrogation of DKK4 functionality thereby facilitating cellular proliferation."
27272409
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"Stabilization of beta-catenin reverses the proliferation suppressive effect of DKK4 in HCC cells cultured in NG."
27272409
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"DICKKOPF-4 is induced by TCF and beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3."
18408752
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"Calcitriol also represses expression of DKK4 in SW480-ADH cells; DKK4 is induced by the TCF7L2 and CTNNB1 pathway and enhances the migratory, invasive and pro angiogenic potential of colorectal cancer."
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"Thus, even though DKK-4 has previously been considered a Wnt " antagonist " similar to the 1,25D-upregulated DKK-1 gene, the fact that DKK-4 is both targeted and upregulated by beta-catenin, and is significantly elevated in colonic tumor tissue [XREF_BIBR, XREF_BIBR] suggests that DKK-4 may in fact possess unique tumorigenic properties."
20043299