IndraLab

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"Notably, ML323, a specific inhibitor of the USP1/UAF1 deubiquitinase complex, inhibited Th17-cell differentiation and promoted Treg-cell differentiation in vitro and in vivo, indicating that ML323 might be a promising candidate for the treatment of diseases associated with an imbalance between Th17 and Treg cells."
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"In light of the role that IDs play in stem cell maintenance and regulation of differentiation, we investigated whether either USP1 or ID knockdown in osteosarcoma would trigger osteoblastic differenti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Recently, the deubiquitinase USP1 was shown to stabilize Id2 and modulate cellular differentiation in osteosarcomas."
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"Furthermore, we provide evidences that Usp1 mediates ISC lineage differentiation via modulating the Notch signaling activity."
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"USP1, in turn, promotes Th17 cell differentiation and attenuates Treg cell differentiation, thereby promoting the development of inflammatory diseases [77]."
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"Considering the action of the proteins ID, USP1 contributes to prevent differentiation mediated by bHLH and, consequently, keep CSC original characteristics."
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"39 For instance, one study indicates that USP1‐UAF1 modulates the differentiation of T helper cell 17 and Treg cells by stabilizing Tafazzin, 40 while another demonstrates that USP1‐UAF1 stabilizes NLR family pyrin domain containing 3 (NLRP3), thereby activating the NLRP3‐mediated inflammatory phenotype."
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"Therefore, SMAD4 induces SHIP-1 in MSCs and represses USP1/Id2, which promotes the differentiation of MSCs [169] (Figure 6A)."
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"Suppression of IDs 1-3 blocked colony formation in soft agar, indicating that the IDs are essential for USP1 transformation of NIH 3T3 cells.Because USP1 overexpression impaired osteoblastic different[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP1 promoted Th17-cell differentiation but attenuated Treg-cell differentiation, thereby promoting the development of inflammatory diseases."
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"Besides, USP1 promotes Th17-cell differentiation but attenuates Treg-cell differentiation (45)."
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