IndraLab

Statements

reach
"USP1 promoted Th17-cell differentiation but attenuated Treg-cell differentiation, thereby promoting the development of inflammatory diseases."
36600049
reach
"Recently, the deubiquitinase USP1 was shown to stabilize Id2 and modulate cellular differentiation in osteosarcomas."
34380645
reach
"In light of the role that IDs play in stem cell maintenance and regulation of differentiation, we investigated whether either USP1 or ID knockdown in osteosarcoma would trigger osteoblastic differenti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21925315
reach
"Considering the action of the proteins ID, USP1 contributes to prevent differentiation mediated by bHLH and, consequently, keep CSC original characteristics."
28302046
reach
"Notably, ML323, a specific inhibitor of the USP1/UAF1 deubiquitinase complex, inhibited Th17-cell differentiation and promoted Treg-cell differentiation in vitro and in vivo, indicating that ML323 might be a promising candidate for the treatment of diseases associated with an imbalance between Th17 and Treg cells."
36600049
reach
"Suppression of IDs 1-3 blocked colony formation in soft agar, indicating that the IDs are essential for USP1 transformation of NIH 3T3 cells.Because USP1 overexpression impaired osteoblastic different[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21925315