IndraLab

Statements

Mutated TSC2 inhibits RPS6KB1. 3 / 3
| 3
reach
"Finally, a tuberin mutant lacking the major PI3K dependent phosphorylation sites blocked the activation of S6K1, suggesting a means by which the PI3K-Akt pathway regulates S6K1 activity [XREF_BIBR]."
19384426
reach
"Furthermore, we find that overexpression of a tuberin mutant lacking the major Akt phosphorylation sites can inhibit growth factor induced activation of S6K1."
12150915
reach
"Finally, we find that a tuberin mutant lacking the major PI3K dependent phosphorylation sites can block the activation of S6K1, suggesting a means by which the PI3K-Akt pathway regulates S6K1 activity."
12150915