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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MDM2 bound to CDKN2A activates TP53. 1 / 1

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"INK4b/ARF/INK4a locus encodes two cyclin dependent kinase inhibitors CDKN2B (p15) and CDKN2A (p16) as well as p19ARF which binds to MDM2 and promotes its degradation resulting in the p53 activation [XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...