IndraLab

Statements

Mebendazole inhibits USP5. 14 / 14
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"Mebendazole downregulated USP5 expression and disrupted the interaction between USP5 and c-Maf , thus leading to increased levels of c-Maf ubiquitination and subsequent c-Maf degradation ."
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"Mebendazole inhibits the USP5 and c-Maf axis and induces c-Maf degradation via the ubiquitin-proteasome pathway."
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"In the above studies , mebendazole was demonstrated to downregulate USP5 expression and disrupt the interaction between USP5 and c-Maf ."
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"The above studies provided strong evidence that mebendazole inhibits the USP5 and c-Maf axis and induces MM cell apoptosis."
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"The above results demonstrated that mebendazole suppressed the USP5 and c-Maf axis and promoted c-Maf degradation; therefore, mebendazole might downregulate the transcriptional activity of c-Maf."
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"The results showed that mebendazole decreased the USP5 content in the c-Maf immunoprecipitates in both exogenous and endogenous contexts, as shown in HEK293T and MM cells, respectively, suggesting that the interaction between USP5 and c-Maf was disrupted by mebendazole."
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"Collectively, these results thus showed marked synergy between mebendazole and USP5 inhibitors or anti-MM drugs such as daunorubicin.Mebendazole delays the growth of human multiple myeloma xenografts in a nude mouse model The above studies provided strong evidence that mebendazole inhibits the USP5 and c-Maf axis and induces MM cell apoptosis."
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"From this screen, we identified mebendazole, an agent widely used for the treatment of human gastrointestinal parasitic infections [XREF_BIBR], selectively induces MM cell apoptosis by targeting USP5 and c-Maf signaling."
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"Mebendazole synergizes with WP1130 , an inhibitor of USP5 , because mebendazole downregulates USP5 expression and WP1130 inhibits USP5 deubiquitinase activity ."
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"From this screen, we identified mebendazole, an agent widely used for the treatment of human gastrointestinal parasitic infections [9], selectively induces MM cell apoptosis by targeting USP5 and c-Maf signaling.Cell culture Human embryonic kidney cells (HEK293T) were maintained in Dulbecco 's modified Eagle 's medium."
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"Mebendazole elicits potent antimyeloma activity by inhibiting the USP5 and c-Maf axis."
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"Mebendazole elicits potent antimyeloma activity by inhibiting the USP5 and c-Maf axis."
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"Mebendazole inhibits USP5 expression and induces c-Maf degradation via the ubiquitin-proteasome pathway ."
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"The above results showed that mebendazole downregulated c-Maf protein expression but had no effect on its mRNA expression ( Fig. 1 ) ; thus , we sought to determine whether mebendazole could suppress USP5 activity via c-Maf ubiquitination ."
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