MDM2 bound to POL2A inhibits TP53. 1 / 1
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"Interestingly, in mammals, a link exists between the regulation of Pol epsilon activity and p53, the functional homologue of SOG1 : MDM2 (Mouse Double Minute 2) can bind the C-terminus of Pol2A and is thought to simultaneously modulate Pol epsilon functions in response to stress and control cell cycle progression by regulating p53 degradation, similar mechanisms might be conserved in plants to maintain genome integrity."