IndraLab

Statements


CEBPA increases the amount of RUNX1. 4 / 4
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"ChIP assays aimed to verify whether runx1 expression was directly regulated by C/ebpalpha."

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"As discussed above, deletion of the RUNX1 gene reduces CEBPA expression, and RUNX1 might directly activate CEBPA transcription."

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"Thus, AML1 and ETO can bind to the transcription factor C/EBPalpha, inhibit C/EBPalpha dependent transcription, and block granulocytic differentiation."

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"AML1 and ETO dominantly inhibits C/EBPalpha transcription and autoregulation of its own promotor [11,26-28]."