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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

CTNNB1 bound to GSK3 activates CTNNB1. 1 / 1

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"Typically, beta-catenin is activated either as a result of GSK-3 inactivation (via its phosphorylation by AKT) or by the recruitment of axin, beta-catenin and GSK-3 to a ternary complex of Frizzled, phosphorylated Dishevelled and phosphorylated LRP5/6 at the plasma membrane (Wnt signaling) [XREF_BIBR, XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...