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Modified SOCS3 decreases the amount of IRS1. 7 / 7
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"The results showed that 100nM insulin could induce SOCS3 mRNA expression but not protein expression, and overexpression of SOCS3 decreased IRS1 protein level, insulin stimulated IRS1 tyrosine phosphorylation, PI3K activation, and Akt phosphorylation, but increased IRS1 serine phosphorylation in porcine primary adipocytes."
20683642
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"In adipocytes, SOCS3 deficiency increases insulin stimulated IRS1 and IRS2 phosphorylation, whereas the overexpression of SOCS3 reduces both IRS1 protein levels and the phosphorylation of IRS1 and IRS2 [XREF_BIBR]."
27337171
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"Consistent with such findings, SOCS3 overexpression decreases the tyrosine phosphorylation levels of IRS1 and inhibits the activity of phosphatidylinositol-3 kinase (PI3K), a downstream signaling element of IRS1, revealing a pivotal role of SOCS3 in insulin resistance."
29973864
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"In adipocytes, SOCS3 deficiency increases insulin stimulated IRS1 and IRS2 phosphorylation, whereas overexpression of SOCS3 reduces both IRS1 protein levels and the phosphorylation of IRS1 and IRS2."
23846596
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"Overexpression of SOCS3 in adipocytes decreases IRS1 protein levels and subsequent insulin stimulated IRS-1 and -2 phosphorylation, decreases p85 binding to IRS-1, and leads to decreased insulin stimulated glucose uptake in adipocytes."
16505233
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"XREF_BIBR Nevertheless, locally, IL-6 induces the expression of SOCS3 in 3T3-L1 adipocytes XREF_BIBR, XREF_BIBR whereas overexpression of SOCS3 in adipocytes reduces IRS-1 protein levels as well as insulin stimulated IRS-1 and IRS-2 phosphorylation and binding of p85 to IRS-1."
24058813
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"Overexpression of SOCS1 or SOCS3 in mouse liver or adipose tissue reduced the expression of IRS1 or IRS2 as well as their tyrosine phosphorylation induced by insulin."
23316186