IndraLab

Statements


Sirolimus decreases the amount of IRS1. 2 / 3
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"Rapamycin inhibits S6K1 dependent IRS-1 serine phosphorylation, increases IRS-1 protein levels, and promotes association of tyrosine phosphorylated IRS-1 with PI3K."

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"These results are in agreement with those of Cerovac et al. in pituitary tumor cells, wherein they demonstrated that octreotide increased the IRS1 phosphorylation level suppressed by rapamycin through SHP1 [XREF_BIBR]."