IndraLab

Statements

TP53 binds MYL6B and MDM2. 5 / 5
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"MYL6B binds both MDM2 and p53 proteins in HCC cell line."
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"Additionally, Co-IP of endogenous MDM2 and p53 proteins with anti-MDM2 and anti-p53 antibodies respectively in Huh7 manifested that endogenous MDM2 and p53 proteins could also interact with endogenous MYL6B (Fig. xref )."
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"But, in this study we found that MYL6B could bind both MDM2 and p53 protein, accelerate the p53 degradation and promote HCC development."
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"Our results provide evidence that MYL6B could bind both MDM2 and p53 proteins."
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"As we have proved that MYL6B could bind both MDM2 and p53 proteins, we further investigated if MYL6B could enhance the interaction between MDM2 and p53."
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