IndraLab

Statements

TCF7L2 binds CTNNB1 and LEF1. 2 / 2
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"The nuclear β-catenin may bind in a complex with the T-cell factor 4 (Tcf4) to the Tcf4/ lymphoid enhancer factor (LEF) binding motif at the MDR1 promoter and thus enhancing promoter activity leading to increased efflux of anticancer drugs of the cell [ xref ]."
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"Upon translocation to the nucleus, β-catenin interacts with T-cell factor 4 (TCF4) and lymphoid enhancer-binding factor 1 (LEF1) to regulate the expression of a wide range of genes at the transcriptional level xref ."
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