IndraLab

Statements

SOCS3 decreases the amount of IRS1. 8 / 8
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"The downregulated expression of GLUT-4 and IRS-1 is driven by IL-6-mediated activation of the JAK–STAT signaling pathway and increased level of SOCS-3 suppressor [108,109]."
31597283
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"Further qPCR data supported that SOCS3 could inhibit the expression of IRS1, LEPR and JAK."
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"SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2."
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"The mechanism by which SOCS3 or SOCS1 reduces IRS-1 levels in muscles requires expression of an E3 ubiquitin ligase consisting of Elongin BC and Cullin proteins."
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"Furthermore, overexpression of SOCS3 decreased the hepatic expressions of IRS1, IRS2 and PI3K, and resulted in glucose intolerance and decrease glucose uptake ."
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"Then SOCS3 can also reduce IRS1 protein levels through inhibiting Jak-STAT signaling pathway."
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"As will be described, an increase in SOCS3 reduces the levels of IRS-1 which interferes with insulin stimulated intracellular signaling."
26444029
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"Determination of insulin resistance-related genes revealed that compared with the blank group, PA treatment significantly enhanced the expression of SAA1 and SOCS3, suppressed the expression of IRS1 and also, exhibited a reduction in the extent of IRS1 phosphorylation (all p < 0.05) (Fig. 2g, h and i)."
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