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NOS2 decreases the amount of IRS1. 3 / 3
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"These findings indicate that iNOS reduces IRS-1 expression in skeletal muscle via proteasome mediated degradation and thereby may contribute to obesity related insulin resistance."
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"Improvement of reduced IRS-1 expression by iNOS deficiency was in agreement with our previous study which showed that iNOS and NO donor reduce IRS-1 expression in cultured skeletal muscle cells, and that iNOS deficiency restored the reduced IRS-1 expression in skeletal muscle of genetically obese, diabetic (ob/ob) mice [XREF_BIBR]."
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"63 In addition, inhibition of iNOS by gene disruption also reversed the decreased IRS-1 expression and thereby improved IRS-1-mediated insulin signaling in skeletal muscle of obese, diabetic (ob/ob) mice."
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