IndraLab

Statements

Mutated CTNNB1 leads to the dephosphorylation of CTNNB1. 2 / 2
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"In CRC cells, the APC and β-catenin mutations not only prevent this normal β-catenin phosphorylation and ubiquitination but also promote abnormal β-catenin stabilization, translocation, and nuclear accumulation (Liu et al., 1999, 2002; Yang et al., 2006)."
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reach
"Activating somatic mutations in the β-catenin gene (CTNNB1 coding) on chromosome 3p occur in almost 100% of SPNs (10), where CTNNB1 mutations disrupt the phosphorylation and degradation of the β-catenin protein."
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