IndraLab

Statements

SOS1 binds VAV1 and GRB2. 5 / 5
| 3 2
sparser
"LAT is tyrosine phosphorylated after TCR engagement and recruits molecular complexes formed by the adaptor protein Grb2 and the exchange factors Vav1 and Sos1 ( xref , xref )."
22732588
sparser
"Grb2 binds constitutively to the proline rich regions of Sos1 and Vav1 through its N-terminal and C-terminal SH3 domains, respectively."
22732588
reach
"Experimental results indicated that after the cross-linking of DAP10 and NKG2D, DAP10 could bind p85 PI3K and the Grb2-Vav-1-SOS1 complex to activate Akt/PKB [75–77]."
32774149
reach
"This adaptor does not contain ITAM domains in its cytoplasmic tail, but it contains one YINM motif, that, upon tyrosine phosphorylation recruits both PI3K and the Grb2, Vav1, and Sos1 complex."
22783260
reach
"Giurisato et al. reported that PI3K catalyzed the generation of PIP3, which can recruit the SOS1-Grb2-Vav1 complex via SOS1 [78]."
32774149