IndraLab

Statements

Aldosterone decreases the amount of IRS1. 3 / 3
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"XREF_BIBR Aldosterone decreases IRS-1 expression and suppresses insulin signaling, XREF_BIBR and clinical reports have indicated that patients with primary aldosteronism commonly have impaired glucose tolerance."
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"Aldosterone induces insulin resistance in isolated vascular smooth muscle cells (VSMC) by reducing IRS1 expression and downstream Akt signaling."
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"Aldosterone (1-100 nmol/L) dose-dependently decreased insulin receptor substrate-1 protein expression with a peak at 18 hours (n = 4)."
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