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Mutated TP53 inhibits cell cycle. 23 / 23
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"Our study indicated that knockdown of mutant p53 by siRNA was able to induce G2-phase cell cycle arrest and apoptosis in 5637 and T24 human bladder cancer cells."
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"There is a rationale to consider p53 as a putative prognostic factor of lung cancer : From a theoretical point of view, the p53 mutation resulting in an inactive protein leads to lack of control of cell proliferation by inhibiting the cell cycle arrest in the Gap 1 phase."
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"Since cell cycle control is directly or indirectly disrupted by TP53 mutations in tumor cells, the overlapping functions in BRmet50 and PMID18271932Sig33 may represent gene expression alterations resulting from the loss of TP53 [XREF_BIBR]."
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"The presence of mutant p53 is characterized by a defective G1 checkpoint, thereby disrupting DNA repair mechanisms (non homologs end joining) in the early part of the cell cycle."
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"Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells."
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"Silencing of mutant p53 induces G2-phase cell cycle arrest in bladder cancer cells."
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"Combined mutations of p53 K117, K161, and K162 to arginine (3KR) in mouse result in loss of induction of apoptosis, senescence, and cell cycle arrest by the mutant p53 3KR protein [XREF_BIBR]."
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"These mutant p53 proteins failed to arrest cells in the G1 phase of the cell cycle in response to IR, whereas, under similar conditions, wild-type p53 induced such arrest."
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"The mutation of p53 impedes cell cycle arrest and apoptosis, thereby favoring continuous cell division of mutant cells."
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"Stable expression of mutant p53 abrogated the G (1)/S (but not the G (2)/M) cell cycle checkpoint and abolished the induction of p21 (WAF1), but had no significant effect on the inhibition of DNA replication in S phase nuclei."
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"Also, silencing of mutant p53 in 5637 (p53 R280T) and T24 (in-frame deletion of Y126) bladder cancer cell lines by p53 siRNA induces G2 arrest of the cell cycle and apoptosis, and increases sensitivity to cisplatin."
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"Mutation of p53 on serine 18 impairs the ability of AMPK to induce cell cycle arrest [XREF_BIBR]."
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"For example, mutant p53 may inactivate cell cycle arrest or DNA repair and influence the sensitivity to chemotherapeutic drugs.The p53His273 mutant did not induce sensitivity to cisplatin and doxorubi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Mouse models have shown that TP53 mutation disrupts cell cycle checkpoint control and DNA damage signaling [XREF_BIBR, XREF_BIBR]."
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"Mutant p53 was experimentally demonstrated to deregulate checkpoints of cell cycle responses to the induction of DNA damage, which accelerated tumour progression via the promotion of genomic instability, cell proliferation and invasion [XREF_BIBR, XREF_BIBR]."
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"Therefore, TP53 mutations, which disrupt cell cycle check points at the G1/S and G2/M transitions, and the amplification of an oncogene (CCND1) or the deletion of suppressor genes (CDKN2A/2B) strongly suggest that the disruption of G1 control is a key event in the development of ESCC (XREF_FIG)."
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"Studies have indicated that knockdown of mutant p53 by siRNA was able to induce G2-phase cell cycle arrest and apoptosis in human bladder cancer cells."
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"These mouse models suggest p53 mutation disrupts cell cycle checkpoint control and DNA damage signaling, and, in the absence of telomerase, permits tumor progression, likely through activation of ALT."
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"Considering that the lower proliferation rate and the slight decrease in the amounts of phospho-histone H3 at Ser 10 in mutant p53 knockdown Panc-1 cells, it is suggestive that knockdown of mutant p53 alone might induce cell cycle arrest before the initiation and/or after the termination of mitosis."
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"P53 mutation prevents growth arrest of damaged cells by regulating cell cycle checkpoints that promote tumorigenesis in various human cancers, including GBM [XREF_BIBR, XREF_BIBR]."
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"Furthermore, silencing of mutant p53 by siRNA was able to induce cell cycle arrest and apoptosis in human prostate and bladder cancer cells."
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"A previous study indicated that small interfering RNA knockdown of mutant p53 induced cell cycle arrest at G 2 phase as well as promoted apoptosis in T24 human bladder cancer cells."
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"Hot spot " mutations of p53 within the DBD usually abolish the transactivation function of p53 (and often create dominant negative inhibitors of wild type p53, with which they form heterotetramers) thereby preventing the expression of cell cycle arresting, pro apoptotic and autophagy inducing genes."
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