IndraLab
Statements
reach
"Mdm2 can also drive the degradation of mutant p53, which indicates that the mutant p53 proteins are not intrinsically resistant to Mdm2 associated degradation, although in tumor cells this regulation is disrupted because p53 dependent transcription of Mdm2 is inhibited by the loss-of-function of mutant p53 or by the dominant negative effect of mutant p53 over WT p53 [XREF_BIBR]."
reach
"Recent evidence demonstrate that two Bcl2 family proteins, BAG2 and BAG5, interact with mutant p53 preventing Mdm2 and CHIP dependent proteasome degradation of mutant p53, this promotes mutant p53 protein accumulation and GOF determining tumor growth, cell migration, and chemoresistance [XREF_BIBR, XREF_BIBR]."