IndraLab

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USP4 deubiquitinates MAP3K7. 20 / 21
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"However, it is not known whether USP4 also deubiquitinates TAK1 in rainbow trout through a similar mechanism."
36372204
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"Mechanistically, p38IP dynamically interacts with TAK1 and promotes USP4 dependent deubiquitination of TAK1."
33469458
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"USP4 deubiquitinates TAK1 in vitro and in vivo."
21331078
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"Moreover, p38IP scaffolds the deubiquitinase USP4 to deubiquitinate TAK1 once TAK1 is activated."
32410369
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"We then analyzed the effect of USP4 knockdown on the TNFalpha induced TAK1 polyubiquitination."
21331078
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"In agreement with a previous study showing that USP4 acts as a deubiquitinase for TAK1 [33], the present study also indicated that USP4 knockdown suppressed TAK1 deubiquitination, but overexpression enhanced its deubiquitination."
37949874
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"USP4 deubiquitinates TAK1 and negatively regulats the IL-1β-, LPS-, and TGF-β-induced NF-κB activation [ 36 ]."
31301291
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"Although it has been reported that USP4 deubiquitinates TAK1 and negatively regulates TNF- and IL-1-induced activation of NF-kappaB, how TAK1 ubiquitination is regulated in adaptive immune cells such as T cells and whether such a regulation regulates T cell mediated immune response remain unknown."
23825189
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"After TAK1 is activated with Lys63 linked polyubiquitination by Dox, USP4 deubiquitinates TAK1 and inhibits TAK1 mediated signaling."
22981905
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"These results indicate that USP4 mainly inhibits inducible TAK1 polyubiquitination and activation whereas CYLD mainly inhibits basal level of TAK1 polyubiquitination and activation."
21331078
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"In addition, USP4 inhibits TNF-alpha-induced activation of NF-kappaB through USP4 deubiquitination of TAK1 XREF_BIBR."
26240016
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"85 The deubiquitinating enzyme ubiquitin‐specific protease 4 (USP4) attenuates major hypertrophic signalling pathways, such as TAK1‐JNK and TAK1‐p38, by removing the K63‐linked polyubiquitination of TAK1."
30102008
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"It has been reported that USP4 acts as a negative regulator to inhibit IL-1β-, LPS- and TGF-β-induced NF-κB activation by deubiquitinating TAK1 [45]."
40102846
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"USP4 and USP18 bind with TAK1 and de-ubiquitinate TAK1 to inhibit its activation [10, 12]."
39033101
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"USP4 deubiquitinates TAK1 in vivo and in vitro."
21331078
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"In conclusion, our results provide evidence that TNFalpha induces association of USP4 with TAK1 which leads to TAK1 deubiquitination in the TNFalpha mediated NF-kappaB activation."
21331078
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"In view of the data presented here and previous reports, we propose a working model (XREF_FIG), in which that TNFalpha rapidly induces Lys63 linked TAK1 polyubiquitnation and binding of USP4 to TAK1, Lys63 linked TAK1 would be rapidly deubiquitinated by USP4 to attenuate the magnitude of TNFalpha induced Lys63 linked TAK1 polyubiquitination and TAK1 mediated IKK and NF-kappaB activation."
21331078
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"It has been reported that USP4 deubiquitinates a large number of target proteins that are involved in the inflammatory response, including tumor necrosis factor receptor-associated Factor 2 (TRAF2), T[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38556105
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"Lys63-linked TAK1 can be rapidly deubiquitinated by USP4, leading to compromised activity [ 42 ]."
34144056
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"Overexpression of wild-type USP4 in Hela cells can inhibit TAK1 polyubiquitination and NF-κB activation, whereas its knockdown can enhance polyubiquitination of TAK1 and phosphorylated IκBα and negatively regulate NF-κB activation induced by IL-1β, LPS and TGFβ (154)."
36969062