IndraLab

Statements

Hexadecanoic acid decreases the amount of IRS1. 8 / 8
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"Incubation with palmitic acid decreased IRS1 expression."
32806641
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"The upregulation of miR-96 in SFA palmitate treated hepatocytes was recently reported to downregulate IRS-1 expression by binding to its 3 ' UTR regions on mRNA, leading to hepatic insulin resistance XREF_BIBR."
29124099
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"Expressions of p-IRS-1 and p-AKT were significantly inhibited by palmitate treatment and those effects were dose- dependently attenuated by APL treatment under insulin stimulated conditions (XREF_FIG)."
27391974
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"Palmitate reduced the expression of INSR and IRS-1 in HepG2 cells substantially compared to the vehicle treated control, whereas the levels of Akt2 and Actin were unaffected by palmitate."
27613089
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"114 In addition, it was found that palmitic acid reduced the expression of insulin receptor substrate 1 in vWAT-derived adipocytes."
36122553
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"We found that palmitic acid can increase the expression of miR-139-5p and reduce IRS1 expression at both the mRNA and protein level."
28346520
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"This study then examined whether the levels of miR-96, which tentatively targets the 3 ' UTRs of INSR and IRS-1, were increased in the palmitate treated HepG2 cells, because the expression of INSR and IRS-1 was decreased by palmitate."
28036389
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"Palmitic acid also decreased IRS1 expression in a dose-dependent manner (p = 0.043 between 25 µM and 50 µM, and p = 0.043 between 25 µM and 100 µM)."
32806641