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EGFR activates RAC1. 39 / 48
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"Tiam1, Vav2, and Dock180 have been implicated in epidermal growth factor receptor (EGFR)-mediated activation of Rac1 and Cdc42."

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"In addition to its role in phosphorylation of p47 phox, c-Src activation also stimulates the transactivation of the epidermal growth factor receptor (EGFR), which evokes phosphatidylinositol 3-kinase-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Consistent with these data, ectopic expression of a PKA inhibitor (PKI) 21 also reduced EGFRvIII promoted p-S of Dock180, p-Erk1/2, p-Akt, Rac1 activity, cell migration and cell proliferation of SNB19 and LN444 glioma cells (XREF_FIG and data not shown)."

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"Our results identify a novel signaling cascade by which EGFRvIII activates Rac1 through PKA dependent phosphorylation of Dock180 S1250, thereby promoting glioblastoma tumorigenesis and invasion."

reach
"These data suggest that p-S-Dock180 S1250 is important for EGFRvIII driven stimulation of p-Erk1/2, Rac1 activity, cell migration, proliferation and survival in vitro."

sparser
"Our results identify a novel signaling cascade by which EGFRvIII activates Rac1 through PKA-dependent phosphorylation of Dock180 S1250 , thereby promoting glioblastoma tumorigenesis and invasion."

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"EGFRvIII stimulates Rac1 signaling through phosphorylation of Dock180 which is mediated by SFKs."

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"Together, our study identifies a bidirectional (phosphorylation and dephosphorylation) regulatory mechanism controlling Tiam1 stability and provides new insights on how EGFR signaling triggers Rac1 activation and cancer development."

sparser
"Data shown in xref suggested a significant activation of Rac1 by C2-CER in INS 832/13 cells [Panel A; left] and normal rat islets [Panel A; right]."

reach
"For example, EGFR has been shown to activate RAC1 by accumulating the RacGEF TIAM1 at the membrane and promoting its GTP-bound state ."

sparser
"Several studies implicate endosomes as the site of Rac1 activation by EGFR and c-MET ( xref )."

sparser
"It was shown that EGFR activates Rac1 by increasing the accumulation of Tiam1 in colon cancer and non-small-cell lung cancer cells."

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"Cells pretreated with AG and stimulated with LPS for 15 min exhibited a 58.3% reduction in Rac1 activity (fold increase of AG/LPS : 1.5 +/- 0.3 vs Veh and LPS : 3.6 +/- 0.4; Fig. 2 B), indicating that[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Vesicular insertion of TRPC5 from a reserve pool of vesicles occurs downstream of EGFR signaling in a Rac1 and phosphatidylinositol 4-phosphate 5-kinase-dependent manner [XREF_BIBR]."

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"Not only Cdc42 but also Rac1 can be activated by Vav2 downstream of EGFR, representing one possible mechanism to compensate for Cdc42 depletion."

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"These results recapitulated our in vitro observations using SNB19 and LN444 cells, further suggesting that PKA induced p-S of Dock180 is critical for EGFRvIII stimulated p-Akt, p-Erk1/2, Rac1 activity and cell migration in glioma cells."

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"Interestingly, another mechanism involved in EGFR induced Rac1 activation was shown in non-small-cell lung cancer and colon cancer cells."

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"The inhibitory effect of RhoG depletion on Rac1 activation is only partial (approximately 40% and 60% inhibition for respectively HGF- and EGF induced Rac1 activity), indicating that cMet and EGFR also can activate Rac1 in a RhoG independent fashion."

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"Collectively, these data suggest that CiaC contributes to Rac1 membrane recruitment and activation, and that maximal C. jejuni invasion of host cells is dependent Rac1 activity that is induced, in part, by EGFR, FAK, PI3 kinase, and Src activation."

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"Here, we show that EGFR activates Rac1 via inducing the accumulation of its specific guanine nucleotide exchange factor, T-cell lymphoma invasion and metastasis 1 (Tiam1) in non-small-cell lung cancer and colon cancer cells."

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"Using an immunoprecipitation (IP) assay to pull down endogenous Dock180 followed by immunoblotting (IB) using a pan anti-p-S antibody, we found that EGFRvIII promoted p-S of Dock180, Rac1 activity and cell migration in SNB19 and LN444 glioma cells that stably expressed EGFRvIII (SNB19 and EGFRvIII and LN444 and EGFRvIII) but not in control SNB19 and LN444 cells expressing GFP (SNB19 and GFP and LN444 and GFP) (XREF_FIG)."

sparser
"We also showed that EGFR-activated Rac1 mediates expression of COX-2 through activation of p38 mitogen-activated protein kinase."

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"Here we report that EGFRvIII induces serine phosphorylation at serine residue 1250 (S1250) of Dock180 (p-Dock180 S1250) and that p-Dock180 S1250 is required for EGFRvIII promoted Rac1 activation, glioblastoma cell growth, survival and invasion in vitro and in vivo."

sparser
"The inhibitory effect of RhoG depletion on Rac1 activation is only partial (approximately 40% and 60% inhibition for respectively HGF- and EGF-induced Rac1 activity), indicating that cMet and EGFR also can activate Rac1 in a RhoG-independent fashion."

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"CH augments membrane depolarization induced pulmonary VSM Ca (2+) sensitization and vasoconstriction through EGFR dependent stimulation of Rac1 and NOX 2."

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"Rac1 activation may be partially mediated by EGFR activation."

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"PKA, but not other AGC protein serine/threonine kinases, 15 mediates EGFRvIII stimulated p-S of Dock180, Rac1 activation and cellular behavior."

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"First, we showed that activation of the epidermal growth factor receptor (EGFR) resulted in increase of Rac1 and loss of stressfibers in podocytes ."

eidos
"First , we showed that activation of the epidermal growth factor receptor ( EGFR ) resulted in increase of Rac1 and loss of stressfibers in podocytes13 ."

sparser
"Here, we show that EGFR activates Rac1 via inducing the accumulation of its specific guanine nucleotide exchange factor, T-cell lymphoma invasion and metastasis 1 (Tiam1) in non-small-cell lung cancer and colon cancer cells."

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"As expected, inhibition of the kinase activity of the EGFR by the pharmacological inhibitor AG1478 abolished activation of both RhoG and Rac1 after 30 s (XREF_FIG E)."

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"Inhibition of EGFR activity with AG1478 abrogated nucleus pulpous cell proliferation (p < 0.05 for each) and attenuated Rac1 and ERK1/2 activation in nucleus pulpous cells subjected to periodic mechanical stress (p < 0.05 for each)."

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"EGFR signaling is known to activate Rac1 [XREF_BIBR], which also regulates actomyosin contractility and cell shape, thus EGFR activated Rac1 may not only support PDGFR inhibitor-IV induced cell rounding but also STAT3 nuclear import."

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"EGFR signalling in lung adenocarcinoma promotes accumulation of the RAC1 specific GEF TIAM1 through phosphorylation by AKT that promotes its interaction with the 14-3-3 scaffold protein, leading to in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"Tiam1, Vav2, and Dock180 have been implicated in epidermal growth factor receptor (EGFR)–mediated activation of Rac1 and Cdc42 ( xref ; xref ; xref ; xref )."

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"As shown in XREF_FIG, when compared to the vector control, expression of Dock180 WT had a minimal impact on EGFRvIII stimulated p-Akt, p-Erk1/2 and Rac1 activity whereas expression of Dock180 S1250L attenuated EGFRvIII stimulation of p-Erk1/2 and Rac1 activity but had no effect on p-Akt."

reach
"The attenuation of EGFR mediated activation of Rac1 and Cdc42 correlates primarily with the duration of Vav2 phosphorylation."

trips
"Here, we show that EGFR activates Rac1 via inducing the accumulation of its specific guanine nucleotide exchange factor, T-cell lymphoma invasion and metastasis 1 (Tiam1) in non-small-cell lung cancer and colon cancer cells."

sparser
"Interestingly, another mechanism involved in EGFR-induced Rac1 activation was shown in non-small-cell lung cancer and colon cancer cells."