IndraLab
Statements
reach
"Using an immunoprecipitation (IP) assay to pull down endogenous Dock180 followed by immunoblotting (IB) using a pan anti-p-S antibody, we found that EGFRvIII promoted p-S of Dock180, Rac1 activity and cell migration in SNB19 and LN444 glioma cells that stably expressed EGFRvIII (SNB19 and EGFRvIII and LN444 and EGFRvIII) but not in control SNB19 and LN444 cells expressing GFP (SNB19 and GFP and LN444 and GFP) (XREF_FIG)."
reach
"As shown in XREF_FIG, when compared to the vector control, expression of Dock180 WT had a minimal impact on EGFRvIII stimulated p-Akt, p-Erk1/2 and Rac1 activity whereas expression of Dock180 S1250L attenuated EGFRvIII stimulation of p-Erk1/2 and Rac1 activity but had no effect on p-Akt."