IndraLab

Statements

TNF decreases the amount of IRS1. 11 / 12
| 11
reach
"In addition, TNF-alpha has been shown to downregulate the expressions of adiponectin, insulin receptor substrate-1 (IRS-1) and peroxisome proliferator activated receptor gamma (Ppar-gamma) in adipocytes [XREF_BIBR], resulting in elevation of insulin and leptin levels but a decrease of adiponectin [XREF_BIBR, XREF_BIBR]."
26247962
reach
"Long-term IL-6 or TNF-alpha treatment inhibits the expression of GLUT4 and IRS-1 in adipose tissue, and in obese patients with T2DM, lower levels of GLUT4 and IRS-1 in VAT were observed."
29967759
reach
"TNF-alpha and IL-6 can cause insulin resistance by suppressing expression of the insulin receptor substrate -1 (IRS-1) and GLUT-4 though activation of NF- K B pathway [XREF_BIBR, XREF_BIBR]."
28166749
reach
"XREF_FIG demonstrates that TNF-alpha treatment decreases the transcriptional levels of IRS-1, GLUT4 and adiponectin in a dose dependent manner and treatment with IKK inhibitor shows that the reduced mRNA levels of our genes of interest were restored, confirming that TNF-alpha exerts its effect through the NF-kappaB pathway in adipocytes."
23383064
reach
"Similar to TNFα, IL-1β was shown to reduce IRS1 expression at both transcriptional and posttranscriptional levels (31), while the IL-1β-mediated deterioration of insulin signaling is largely due to the IL-6 production and suppressor of cytokine signaling 3 (SOCS3) induction in 3T3-L1 adipocytes (32)."
34869524
reach
"Our results demonstrated that : (1) TNF-alpha triggered IRS-1 phosphorylation on serine 307 and decreased IRS-1 protein level; (2) over-expression of PP4 not only induced IRS-1 phosphorylation and IRS-1 protein reduction, but amplified the effect of TNF-alpha on IRS-1; (3) suppression of PP4 expression and activity restored the effect of TNF-alpha on IRS-1."
26666849
reach
"IL-6 and TNF-alpha can reduce the expression of GLUT4 and IRS-1, and reduce the glucose transport [XREF_BIBR]."
26503060
reach
"Our data demonstrated that TNF-alpha significantly reduced levels of glucose consumption and IRS-1 protein expression, while TNF-alpha increased the phosphorylation of IRS-1 Ser307 in adipocytes 24 h after the challenge, suggesting that TNF-alpha induced a condition with the occurrence of insulin resistance."
25355439
reach
"Both IL-6 and TNF may inhibit the transcription of IRS-1 and glucose transporter (GLUT) -4 genes, thus reducing glucose transport and enhancing insulin resistance in obese patients [XREF_BIBR]."
22691241
reach
"Reportedly, TNF-alpha downregulates IRS-1 and GLUT4 expression in adipose tissue, resulting in insulin resistance in terms of adipocyte glucose uptake."
22396205
reach
"It was shown that TNFalpha downregulates the expression of insulin receptor substrate 1 (IRS-1) and glucose transporter type 4 (GLUT4), and inhibits the activity of AMPK activity."
33897419