IndraLab
Statements
reach
"Indeed, it is known that the NOS synthesis is regulated through the activation of the extracellular signal regulated protein kinase (ERK) and the UCHL1 protein has been shown to drastically decrease the activation of ERK XREF_BIBR, arguing for an inactivation of the NOS system in A. algerae infected HFF cells."
reach
"While UCH-L1 has been shown to inhibit alpha 2 -adrenergic receptor (AR) agonist mediated activation of ERK via a direct association with alpha 2A -AR receptor implicating a role of UCH-L1 in neuro-protection XREF_BIBR, it has also been documented that UCH-L1 up-regulates oncogenic beta-catenin and TCF and Akt signaling to induce tumor cell proliferation and migration contributing to tumor progression XREF_BIBR, XREF_BIBR."