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USP10 inhibits apoptotic process. 49 / 49
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"Consistently , in our study , we also demonstrated that USP10 inhibited hepatocyte inflammation and apoptosis in hepatocytes following H / R stimulation ( Figure 5 ) ."
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"We previously reported that USP10 inhibits oxidant-induced apoptosis by reducing ROS production in mouse embryonic fibroblasts (MEFs) ( xref )."
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"Collectively, these results indicate that USP10 inhibits cytokine deprivation-induced apoptosis of IVC-LSK cells in a deubiquitinase-dependent but ROS-independent manner."
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"A deubiquitinase-inactive USP10 mutant (USP10/C418A) did not inhibit cytokine deprivation-induced apoptosis of IVC-LSK cells, indicating that a factor deubiquitinated by USP10 inhibits apoptosis of IVC-LSK cells."
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"Biologically, silenced USP10 in lung cancer cells contributes to the elongated cell survival and depressed apoptosis, partially through deubiquitinating the mismatch repair protein MSH2 [XREF_BIBR], or negatively modulating EIF4G1 mediated functions [XREF_BIBR]."
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"Upon exposure to an oxidant, USP10 inhibits ROS-dependent apoptosis by reducing ROS production ( xref )."
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"USP10 was shown to decrease the generation of reactive oxygen species (ROS) when exposed to an oxidant, hence preventing ROS-dependent apoptosis (43)."
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"These results indicate that USP10 inhibits apoptosis by two distinct mechanisms: one is deubiquitinase-independent/ROS-dependent and the other is deubiquitinase-dependent/ROS-independent."
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"XREF_FIG, overexpression of either HDAC6 or USP10 in USP10 knockdown cells significantly increased cell survival post-cisplatin treatment and reduced apoptosis as shown by the level of cleaved PARP-1."
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"Suppression of the USP10 and CCND1 axis induces glioblastoma cell apoptosis."
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"Thus, USP10 induced aggregates and aggresomes might inhibit apoptosis by reducing the amount of ubiquitinated protein oligomers."
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"However, we could not exclude the possibility that USP10 inhibits apoptosis by promoting degradation of pro apoptotic protein (s) by aggresome mediated autophagy."
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"USP10 inhibits apoptosis by two distinct mechanisms : deubiquitinase-independent / ROS-dependent and deubiquitinase-dependent / ROS-independent ."
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"As shown in xref and xref , downregulation of USP10 inhibited IR-induced apoptosis in HCT116 p53 +/+ cells."
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"Inhibition of USP10 induces myeloma cell apoptosis by promoting cyclin D3 degradation."
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"USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells."
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"Thus, USP10 isan essential deubiquitinase for mouse hematopoiesis and functions by inhibiting apoptosis of HSPCs including LT-HSCs."
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"USP10 also has deubiquitinase-independent functions, such that USP10 inhibits apoptosis by reducing reactive oxygen species (ROS) production induced by an oxidative stress inducer arsenite ( xref )."
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"These results suggest that inhibition of HSC apoptosis is a function of USP10 to maintain the number of HSCs in FL, and that USP10 selectively inhibits apoptosis of HSCs, MPPs, and HPCs but not more differentiated LCPs."
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"We previously reported that USP10 inhibits oxidant induced apoptosis by reducing ROS production in mouse embryonic fibroblasts (MEFs)."
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"Unlike cytokine deprivation induced apoptosis of IVC-LSK cells, oxidant induced apoptosis of MEFs was inhibited by USP10 and C418A but notUSP10/77 -792 or USP10/95 -792."
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"Collectively, these results indicate that USP10 inhibits cytokine deprivation induced apoptosis of IVC-LSK cells in a deubiquitinase dependent but ROS independent manner."
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"USP10 knockdown promotes apoptosis in hepatic I / R. ( A , B ) The mRNA levels of cell death-related genes ( Bad , Bax and Bcl2 ) in livers from USP10-HZ and WT mice in I / R groups at 6 h ( A ) and 24 h ( B ) post-reperfusion and in sham controls ( n = 4 per group ) ."
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"These results suggest that USP10 inhibits apoptosis of HSPCs by deubiquitinating molecule (s) other than the ones analyzed here."
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"USP10 alleviates sepsis-induced renal dysfunction and reduces renal tubular epithelial cell apoptosis and oxidative stress."
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"These results suggest that SCF signaling and its associated factors function in USP10 mediated inhibition of HSPC apoptosis."
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"In HTLV-1-transformed cells that do not express detectable Tax protein, USP10 (ubiquitin-specific peptidase 10) inhibits stress-induced reactive oxygen species (ROS) production and apoptosis."
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"USP10 Inhibited Inflammation and Apoptosis in Hepatocytes After H / R Treatment To validate whether USP10 directly influences inflammation and apoptosis in hepatocytes , we detected inflammation and apoptosis in H / R-treated primary hepatocytes isolated from USP10-HZ and WT mice ."
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"Since cell-surface expression levels of c-KIT on USP10-KO HSPCs were normal, downstream molecules involved in intracellular SCF signaling are likely to play a role in USP10 mediated inhibition of apoptosis."
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"For example, inhibiting USP10 reduces the production of reactive oxygen species and suppresses apoptosis and the formation of SGs (stress granules) [78]."
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"Upon exposure to an oxidant, USP10 inhibits ROS dependent apoptosis by reducing ROS production."
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"MTT assay and flow cytometry revealed that LPS induction led to decreased cell viability and increased cell apoptosis, which was reversed by USP10 overexpression (Fig. 5B-C)."
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"These research findings are similar to our findings, indicating that USP10 can promote cell proliferation and inhibit apoptosis to enhance tumor cell resistance to platinum-based drugs.In summary, our[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, upon exposure to external stress such as high concentrations of hydrogen peroxide [65], the inhibition of USP10 by G3BP1 is abrogated and USP10 is induced to phosphorylate by ataxia-telangiectasia-mutated protein (ATM) or activated by ATM-phosphorylated protein, thereby reducing ROS production and apoptosis [64]."
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"Additionally, USP10 overexpression inhibited hepatocyte inflammation and apoptosis in hepatic I/R injury in vitro and in vivo."
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"Knockdown of USP10 in lung cancer cells exhibits increased cell survival and decreased apoptosis upon the treatment of DNA methylating agent N-methyl-N '-nitro-N-nitrosoguanidine (MNNG) and antimetabolite 6-thioguanine (6-TG)."
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"Since aberrant ROS production has been shown to be a critical apoptosis inducer of HSCs under basal and stress conditions, it was initially assumed that USP10 inhibits apoptosis of HSCs by inhibiting ROS production."
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"These results indicate that USP10 inhibits apoptosis by two distinct mechanisms : one is deubiquitinase-independent and ROS-dependent and the other is deubiquitinase-dependent and ROS-independent."
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"Thus, USP10 interaction with G3BP1 and the incorporation of USP10 into stress granules are dispensable for USP10 inhibition of cytokine deprivation induced apoptosis in FL HSPCs."
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"On exposure to arsenic, an oxidative stress inducer, USP10 is recruited into stress granules (SGs), and USP10 containing SGs reduce reactive oxygen species (ROS) production and inhibit ROS dependent apoptosis."
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"Also, levels of this m A-repelled protein were decreased in H9c2 cells after the H/R insult, and overexpression of USP10 increased the viability and suppressed the apoptosis of H/R-induced cells [54]."
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"USP10 also has deubiquitinase independent functions, such that USP10 inhibits apoptosis by reducing reactive oxygen species (ROS) production induced by an oxidative stress inducer arsenite."
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"In this study , we also demonstrated that USP10 inhibited hepatocyte inflammation and apoptosis , depending on TAK1 phosphorylation , and JNK and p38 activation ( Figure 6 ) ."
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"USP10 overexpression promoted ectopic endometrial stromal cell migration and proliferation, suppressed cell apoptosis, and activated MEK and ERK signaling that is a critical downstream target of the serine/threonine protein kinase Raf-1, which was significantly blocked by PD98059."
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"A recent study [XREF_BIBR] suggested that the balance between G3BP1 and one of its binding partners Ubiquitin specific protease 10 (USP10) coordinately regulates ROS levels and inhibits apoptosis when both proteins are colocalized in SGs (induced by arsenite stress), but not in response to hydrogen peroxide, which did not induce SGs under the conditions they employed."
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"However, we could not exclude the possibility that USP10 inhibits apoptosis by promoting degradation of pro-apoptotic protein(s) by aggresome-mediated autophagy."
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"Our study reports for the first time that USP10 alleviates sepsis-induced renal dysfunction, and reduces renal tubular epithelial cell apoptosis and oxidative stress.USP10 is closely related to many biological processes."
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"Notably, USP10 was found to inhibit tubular epithelial cell apoptosis and activate the NRF2/ARE pathway via Sirtuin 6 (Sirt6) (Gao et al. 2021)."
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"In addition, upregulation of USP10 can suppress myocardial fibrosis and prevent cardiomyocyte apoptosis in cases of cardiac dysfunction (Lu et al. 2021; Zhang et al. 2020)."
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