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USP10 inhibits apoptotic process. 43 / 43
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"USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells."
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"Collectively, these results indicate that USP10 inhibits cytokine deprivation induced apoptosis of IVC-LSK cells in a deubiquitinase dependent but ROS independent manner."
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"XREF_FIG, overexpression of either HDAC6 or USP10 in USP10 knockdown cells significantly increased cell survival post-cisplatin treatment and reduced apoptosis as shown by the level of cleaved PARP-1."
32382008
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"USP10 also has deubiquitinase independent functions, such that USP10 inhibits apoptosis by reducing reactive oxygen species (ROS) production induced by an oxidative stress inducer arsenite."
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"We previously reported that USP10 inhibits oxidant-induced apoptosis by reducing ROS production in mouse embryonic fibroblasts (MEFs) ( xref )."
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"USP10 alleviates sepsis-induced renal dysfunction and reduces renal tubular epithelial cell apoptosis and oxidative stress."
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"Consistently , in our study , we also demonstrated that USP10 inhibited hepatocyte inflammation and apoptosis in hepatocytes following H / R stimulation ( Figure 5 ) ."
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"USP10 also has deubiquitinase-independent functions, such that USP10 inhibits apoptosis by reducing reactive oxygen species (ROS) production induced by an oxidative stress inducer arsenite ( xref )."
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"USP10 inhibits apoptosis by two distinct mechanisms : deubiquitinase-independent / ROS-dependent and deubiquitinase-dependent / ROS-independent ."
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"Additionally, USP10 overexpression inhibited hepatocyte inflammation and apoptosis in hepatic I/R injury in vitro and in vivo."
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"Since aberrant ROS production has been shown to be a critical apoptosis inducer of HSCs under basal and stress conditions, it was initially assumed that USP10 inhibits apoptosis of HSCs by inhibiting ROS production."
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"USP10 knockdown promotes apoptosis in hepatic I / R. ( A , B ) The mRNA levels of cell death-related genes ( Bad , Bax and Bcl2 ) in livers from USP10-HZ and WT mice in I / R groups at 6 h ( A ) and 24 h ( B ) post-reperfusion and in sham controls ( n = 4 per group ) ."
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"These results suggest that SCF signaling and its associated factors function in USP10 mediated inhibition of HSPC apoptosis."
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"However, we could not exclude the possibility that USP10 inhibits apoptosis by promoting degradation of pro apoptotic protein (s) by aggresome mediated autophagy."
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"As shown in xref and xref , downregulation of USP10 inhibited IR-induced apoptosis in HCT116 p53 +/+ cells."
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"These results suggest that inhibition of HSC apoptosis is a function of USP10 to maintain the number of HSCs in FL, and that USP10 selectively inhibits apoptosis of HSCs, MPPs, and HPCs but not more differentiated LCPs."
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"USP10 overexpression promoted ectopic endometrial stromal cell migration and proliferation, suppressed cell apoptosis, and activated MEK and ERK signaling that is a critical downstream target of the serine/threonine protein kinase Raf-1, which was significantly blocked by PD98059."
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"For example, inhibiting USP10 reduces the production of reactive oxygen species and suppresses apoptosis and the formation of SGs (stress granules) [78]."
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"Thus, USP10 isan essential deubiquitinase for mouse hematopoiesis and functions by inhibiting apoptosis of HSPCs including LT-HSCs."
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"Upon exposure to an oxidant, USP10 inhibits ROS dependent apoptosis by reducing ROS production."
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"MTT assay and flow cytometry revealed that LPS induction led to decreased cell viability and increased cell apoptosis, which was reversed by USP10 overexpression (Fig. 5B-C)."
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"Inhibition of USP10 induces myeloma cell apoptosis by promoting cyclin D3 degradation."
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"Thus, USP10 induced aggregates and aggresomes might inhibit apoptosis by reducing the amount of ubiquitinated protein oligomers."
30469013
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"USP10 Inhibited Inflammation and Apoptosis in Hepatocytes After H / R Treatment To validate whether USP10 directly influences inflammation and apoptosis in hepatocytes , we detected inflammation and apoptosis in H / R-treated primary hepatocytes isolated from USP10-HZ and WT mice ."
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"A deubiquitinase-inactive USP10 mutant (USP10/C418A) did not inhibit cytokine deprivation-induced apoptosis of IVC-LSK cells, indicating that a factor deubiquitinated by USP10 inhibits apoptosis of IVC-LSK cells."
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"However, we could not exclude the possibility that USP10 inhibits apoptosis by promoting degradation of pro-apoptotic protein(s) by aggresome-mediated autophagy."
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"Upon exposure to an oxidant, USP10 inhibits ROS-dependent apoptosis by reducing ROS production ( xref )."
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"On exposure to arsenic, an oxidative stress inducer, USP10 is recruited into stress granules (SGs), and USP10 containing SGs reduce reactive oxygen species (ROS) production and inhibit ROS dependent apoptosis."
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"Biologically, silenced USP10 in lung cancer cells contributes to the elongated cell survival and depressed apoptosis, partially through deubiquitinating the mismatch repair protein MSH2 [XREF_BIBR], or negatively modulating EIF4G1 mediated functions [XREF_BIBR]."
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"Knockdown of USP10 in lung cancer cells exhibits increased cell survival and decreased apoptosis upon the treatment of DNA methylating agent N-methyl-N '-nitro-N-nitrosoguanidine (MNNG) and antimetabolite 6-thioguanine (6-TG)."
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"Suppression of the USP10 and CCND1 axis induces glioblastoma cell apoptosis."
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"A recent study [XREF_BIBR] suggested that the balance between G3BP1 and one of its binding partners Ubiquitin specific protease 10 (USP10) coordinately regulates ROS levels and inhibits apoptosis when both proteins are colocalized in SGs (induced by arsenite stress), but not in response to hydrogen peroxide, which did not induce SGs under the conditions they employed."
25482014
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"Since cell-surface expression levels of c-KIT on USP10-KO HSPCs were normal, downstream molecules involved in intracellular SCF signaling are likely to play a role in USP10 mediated inhibition of apoptosis."
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"Unlike cytokine deprivation induced apoptosis of IVC-LSK cells, oxidant induced apoptosis of MEFs was inhibited by USP10 and C418A but notUSP10/77 -792 or USP10/95 -792."
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"These results suggest that USP10 inhibits apoptosis of HSPCs by deubiquitinating molecule (s) other than the ones analyzed here."
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"We previously reported that USP10 inhibits oxidant induced apoptosis by reducing ROS production in mouse embryonic fibroblasts (MEFs)."
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"Our study reports for the first time that USP10 alleviates sepsis-induced renal dysfunction, and reduces renal tubular epithelial cell apoptosis and oxidative stress.USP10 is closely related to many biological processes."
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"Furthermore, depletion of USP10 in lung cancer cells causes decreased apoptosis and increased cell survival upon treatment with DNA damaging agents."
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"Thus, USP10 interaction with G3BP1 and the incorporation of USP10 into stress granules are dispensable for USP10 inhibition of cytokine deprivation induced apoptosis in FL HSPCs."
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"These results indicate that USP10 inhibits apoptosis by two distinct mechanisms : one is deubiquitinase-independent and ROS-dependent and the other is deubiquitinase-dependent and ROS-independent."
27974222
sparser
"These results indicate that USP10 inhibits apoptosis by two distinct mechanisms: one is deubiquitinase-independent/ROS-dependent and the other is deubiquitinase-dependent/ROS-independent."
27974222
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"In this study , we also demonstrated that USP10 inhibited hepatocyte inflammation and apoptosis , depending on TAK1 phosphorylation , and JNK and p38 activation ( Figure 6 ) ."
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"Collectively, these results indicate that USP10 inhibits cytokine deprivation-induced apoptosis of IVC-LSK cells in a deubiquitinase-dependent but ROS-independent manner."
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