IndraLab

Statements


Phosphorylated CTNNB1 leads to the deubiquitination of CTNNB1. 3 / 3
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"In canonical Wnt signaling, phosphorylation of beta-catenin at specific locations by glycogen synthase kinase-3beta (GSK-3beta) leads to ubiquitination and degradation of beta-catenin [XREF_BIBR, XREF_BIBR]."

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"On the other hand, phosphorylation of beta-catenin leads to ubiquitination and degradation of beta-catenin XREF_BIBR, XREF_BIBR."

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"Inactivation of GSK3beta results to inability of beta-catenin phosphorylation, which would decrease the ubiquitination and proteolysis of beta-catenin."