IndraLab

Statements

TP53 binds MDM2 and PML. 8 / 8
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"This sequestration of MDM2 is counteracted by MAP kinase 7 (MAPK7) and the spindle-assemble checkpoint protein MAD1 (MAD1L1), which block the interaction between PML and MDM2 leading to p53 degradation [ xref , xref ]."
36230470
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"In this study, we report an in vivo and in vitro interaction between PML and MDM2 which is independent of p53."
12759344
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"PML may form trimeric PML-MDM2-p53 complexes and stabilize p53 in UV-damaged cells ( Kurki et al., 2003 )."
30292834
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"Mad1 regulates the interaction of MDM2 with PML and p53."
30948704
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"Similarly, the Big MAP Kinase 1 (BMK1) down-regulates PML protein levels by phosphorylating PML at S403 and T409 and promoting its degradation, thereby disrupting the interaction between PML and Mdm2 and suppressing p53 activity [ xref , xref ]."
26539288
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"Interestingly, PML can bind to Mdm2 and p53 [22,72,73] , and Mdm2 and PML can form trimeric complexes, which may prevent Mdm2-mediated p53 degradation [22] ."
15865933
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"We reported previously an in vivo and in vitro interaction between PML and MDM2 that is independent of p53."
14507915
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"BMK1 associates with PML and disrupts the interaction between PML and MDM2 (the major E3 ubiquitin ligase for p53), which leads to p53 stabilization."
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