IndraLab

Statements


Mutated MDM2 activates TP53. 5 / 5
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"Thus, ligase dead mutants of Mdm2 did not act in a dominant negative manner to reactivate p53 and they are not oncogenes in MCF10A cells."

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"For example, a point mutation of the Mdm2 RING domain that destroys RING structure (C462A) and blocks Mdm2 ligase activity triggers p53 stabilization and leads to p53 dependent embryonic lethality."

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"Thus, any MDM2 mutation can lead to a loss of this feedback loop control and inhibit the tumor suppressing activity of p53 as demonstrated in XREF_FIG."

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"The existence of a missing factor has also been suggested by the observation that some MDM2 mutants retain ubiquitin ligase activity but do not target p53 for degradation [41,83-85]."

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"Expression of wild-type MDM2, but not the mutant MDM2 defective either in Rb interaction or in RING finger domain, promotes cell cycle S phase entry independent of p53."