IndraLab

Statements

KLF10 binds CTNNB1 and LEF1. 3 / 3
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"The C-terminal TIEG1 expression construct primarily interacted with Lef1 and β-catenin in the nucleus (Figure xref )."
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"We also demonstrated that TIEG1 interacts with both Lef1 and β-catenin proteins suggesting that it associates with these factors as part of a larger transcriptional complex on Tcf/Lef enhancer elements encoded within classic canonical Wnt target genes."
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"In addition to modulating β-catenin nuclear localization, we also reveal that TIEG1 interacts with Lef1 and β-catenin on Tcf/Lef enhancer elements resulting in enhancement of the canonical Wnt signaling pathway in osteoblasts."
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