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Ubiquitinated CTNNB1 activates CTNNB1. 1 / 1

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"By inducing the ubiquitination of β-catenin, NEDD4L could repress the activation of the Wnt/β-catenin signaling pathway, and restrict the CTHRC1/HIF-1α axis due to the CTHRC1 expression-promoting effect of β-catenin; then, CTHRC1 and HIF-1α suppression could attenuate the viability and differentiation of LFs, thereby impeding the formation and progression of IPF."

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IndraLab

Statements

Ubiquitinated CTNNB1 activates CTNNB1. 1 / 1

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