IndraLab

Statements


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sparser
"Moreover, IRTKS variant with IMD deletion failed to enhance MDM2-induced p53 ubiquitination ( xref ), indicating that the IMD region which was required for the physical association of IRTKS with both MDM2 and p53, was crucial for IRTKS-induced p53 ubiquitination."

sparser
"IRTKS interacted directly with both p53 and MDM2 through its IMD domain, and enhances low level MDM2-mediated p53 ubiquitination in vivo and in vitro."

sparser
"Our data indicated that the IMD domain was required for IRTKS binding to p53 and MDM2 and for its effect on MDM2-mediated p53 ubiquitination."

sparser
"We then investigated the effect of DNA damage on the interaction of IRTKS, p53 and MDM2."

sparser
"These data suggested that DNA damages affected the IRTKS-p53 and IRTKS-MDM2 interactions differently and specifically."