IndraLab

Statements

Modified PTEN decreases the amount of phosphatidylinositol trisphosphate. 7 / 7
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"Loss of PTEN increases PIP3 levels, resulting in constitutive activation of Akt signaling."
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"Therefore, we speculated that PTEN may be involved in regulating p-AKT levels for insect diapause.In the present paper, we report that PTEN expression levels in brains of diapause destined pupae are s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Not surprisingly, genetic loss of PTEN enhanced PIP3 levels and increased the amount of polymerized actin."
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"Consistent with immunoblotting using anti-phospho-AKT antibodies, quantitative live-cell imaging using a PIP3 biosensor, RFP-PH AKT, which specifically binds to PIP3 in the plasma membrane, showed that expression of PTEN WT -GFP greatly reduced PIP3 levels."
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"Thus, the loss in PTEN causes elevation of intracellular PIP3 level that stimulates Akt kianse activity."
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"Loss of PTEN leads to constitutively high levels of PIP3, which mimics the state of growth factor stimulation of hyperactivated PI3K."
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"The loss of PTEN leads to constitutively high levels of PIP3, which promotes the recruitment of a subset of proteins that contain a pleckstrin homology domain to cellular membranes, including PDK1 and Akt kinase."
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