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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MDM2 bound to RB1 activates TP53. 1 / 1

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"For example, binding of p14 ARF and pRb to the MDM2 acidic region have been shown to increase p53 stability, while interaction with the chromatin remodeling protein, p300, stimulates MDM2 dependent p53 degradation [XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...