IndraLab

Statements

SOS1 binds GRB2 and csh3. 3 / 3
| 3
sparser
"Both the N- and C-SH3 domains of grb2 interact with sos1 ( xref )."
16520382
sparser
"As shown in and , the binding of nSH3 and cSH3 domains of Grb2 to Sos1 employs distinct thermodynamic mechanisms."
18778683
sparser
"Such orientational constraint imposed upon Grb2-Sos1 assembly by the cSH3 domain coupled with conformational heterogeneity resulting from the promiscuity of nSH3 domain may be an important determinant of regulating the activation of downstream molecules such as Ras."
19323566