IndraLab

Statements

reach
"USP18 induction by HIV-1 tunes the IFN response to optimal levels allowing for efficient transcription from the HIV-1 LTR promoter while minimizing the T1 IFN-induced antiviral response that would otherwise restrict viral replication and spread."
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reach
"By providing exogenous IFN‐β, we were able to demonstrate that lack of USP18 makes cells more sensitive to the effects of IFN.The strategy used by HIV‐1 for transcription from its LTR promoter utilizes transcription factors such as NFκB, NFAT, and IRFs,73, 74 that would normally be present in a cell that has detected a viral infection and has initiated an antiviral response."
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reach
"The average RQ of the USP18 −/− clones divided by the average RQ of the USP18 +/+ clones are expressed as fold change The strategy used by HIV-1 for transcription from its LTR promoter utilizes transcription factors such as NF B, NFAT, and IRFs, 73,74 that would normally be present in a cell that has detected a viral infection and has initiated an antiviral response."
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