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RUNX2 binds CTNNB1 and LEF1. 2 / 2

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"Conversely, a ternary complex composed of β-catenin::LEF1::Runx2 was found to inhibit Runx2 from binding to DNA in mouse osteoblast cells ( xref )."

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"Menin is considered to support BMP-2- and Runx2-induced differentiation of mesenchymal cells into osteoblasts by interacting with Smad1/5, Runx2, β-catenin and LEF-1, although it has different effects on osteoblasts at later differentiation stages through TGF-β-Smad3 and AP-1 pathways."

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IndraLab

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RUNX2 binds CTNNB1 and LEF1. 2 / 2

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