IndraLab

Statements

CTNNB1 bound to TCF/LEF activates CTNNB1. 2 / 2
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"Beta-catenin then translocates to the nucleus and interacts with TCF/LEF which stimulates the beta-catenin downstream target genes (PDK, MTC-1, cMyc, cyclin D1, Cox 2, AXIN 2, etc.) [XREF_BIBR - XREF_BIBR]."
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"This leads to the stabilization and accumulation of cytoplasmic beta-catenin, which then enters the nucleus, binds TCF/LEF proteins and leads to the subsequent dissociation of groucho co-repressors, recruitment of the coactivator p300 and activation of beta-catenin target genes XREF_BIBR - XREF_BIBR."
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