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AGT decreases the amount of IRS1. 2 / 2
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"AngII also decreases IRS-1 protein levels in vascular smooth muscle cells and induces SOCS-3 (suppressor of cytokine signalling-3), which further inhibits insulin signalling and insulin stimulated glucose disposal [XREF_BIBR, XREF_BIBR]."

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"We previously demonstrated that Ang II decreases IRS-1 protein expression, and consequently attenuates glucose metabolism mediated via the phosphatidylinositol 3 kinase-Akt signaling pathway."