IndraLab

Statements

MALT1 inhibits CYLD. 9 / 10
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"T-cell receptor induced JNK activation requires proteolytic inactivation of CYLD by MALT1."
21448133
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"CYLD but Not RelB Nor Regnase-1 Is Reduced by MALT1 Activity in Macrophages."
29018444
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"In summary, our study demonstrates for the first time that (i) MALT1 modulates TLR7 agonist- and IAV induced MMP-9 response in alveolar macrophages; (ii) MALT1 mediates CYLD reduction in macrophages upon TLR7 stimulation; (iii) MMP-9 production in alveolar macrophages is through NF-kappaB but not AP-1; and that (iv) MALT1 deficiency results in reduced IAV induced disease severity."
29018444
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"Human paracaspase MALT1 is central to plasticity of lymphocytes as MALT1 proteolytic inactivation of CYLD ensures sustained activation of NFkappaB as well as RIG1 for providing innate immune response [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25500259
sparser
"Here, we show that T-cell receptors (TCR) activation, as well as overexpression of the oncogenic API2-MALT1 fusion protein, results in proteolytic inactivation of CYLD by MALT1, which is specifically required for c-jun N-terminal kinase (JNK) activation and the inducible expression of a subset of genes."
21448133
reach
"Here, we show that T-cell receptors (TCR) activation, as well as overexpression of the oncogenic API2-MALT1 fusion protein, results in proteolytic inactivation of CYLD by MALT1, which is specifically required for c-jun N-terminal kinase (JNK) activation and the inducible expression of a subset of genes."
21448133
sparser
"Human paracaspase MALT1 is central to plasticity of lymphocytes as MALT1 proteolytic inactivation of CYLD ensures sustained activation of NFκB as well as RIG1 for providing innate immune response ( Be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25500259
reach
"Inhibition of MALT1 activity by z-VRPR-fmk reversed CYLD degradation slightly but the difference did not reach statistical significance."
29018444
sparser
"MALT1 proteolytically cleaves and inactivates A20 as well as CYLD, two negative regulators of NF-κB signaling ( xref , xref )."
22224767