IndraLab

Statements

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"Then, acute reduction in neuronal activity occurs, which arises from voltage-dependent inactivation of sodium channels, while longer-term inhibition of activity occurs in response to the associated rise in intracellular Ca 2+ and associated calcium dependent processes [ xref ]."
20021438
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"Experimental data revealed that A1180V channels exhibited a negative transform of voltage-dependent inactivation of the cardiac sodium channels, which lead to a rate-dependent sodium current reduction, and a moderate increase in late sodium current."
24227891
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"Then, acute reduction in neuronal activity occurs, which arises from voltage-dependent inactivation of sodium channels, while longer-term inhibition of activity occurs in response to the associated rise in intracellular Ca2 + and associated calcium dependent processes ( xref and xref )."
21256210
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"This is an important issue to address because plateau potentials can lead to spike failures by impairing the voltage-dependent de-inactivation of host-cell sodium channels; ChETA mutations have previously been shown to virtually eliminate the plateau potential in fast-spiking interneurons xref , but left unclear the best strategy to use for pyramidal neurons because those ChETAs did not give rise to strong photocurrents in cultured pyramidal cells ( xref )."
22179551
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"When g(K,ATP) is lower than 72 nS, the model enters a stable depolarised state, and firing of action potentials is inhibited due to voltage-dependent inactivation of the Na(+) and T-type Ca(2+) currents."
19669464
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"In this study, the effects of BmK AS, a sodium channel-specific modulator from Chinese scorpion Buthus martensi Karsch, on the voltage-dependent activation and inactivation of Na v 1.2 were examined before and after PKA activation."
24430351
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"Together with the electrophysiological findings showing that the intrinsic properties, such as voltage-dependent activation and inactivation of Nav1.8 sodium channels, remained unchanged after the inoculation of tumor cells, the increased expression of Nav1.8 on the cell membrane provides a possible explanation for the enhanced density of Nav1.8- mediated sodium current in the DRG neurons of MRMT-1-treated rats, which actually represents the functional upregulation of Nav1.8 sodium channels in the DRG neurons of bone cancer rats."
25503076
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"Filament breakup was due to SAC recruitment in regions of high fiber stretch (away from the spiral core), resulting in voltage-dependent inactivation of sodium channels there, a mechanism for breakup that is different from other known mechanisms for wavebreak such as restitution. xref – xref The simulations results thus provided an alternative explanation for the degeneration of VT into VF."
21212393
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"Loss of Na V 1.1 did not change voltage-dependent activation or inactivation of sodium channels in hippocampal neurons ( xref )."
19005038
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"Subsequently, Na v 1.8 expressed in mammalian neuronal cells revealed concentration- and voltage-dependent inhibition of Na v 1.8 by clinically relevant concentrations of isoflurane similar to other subtypes (Herold et al., xref ; Figure xref A, upper panel)."
22479247
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"Voltage-dependent activation or inactivation of sodium channels was unchanged ( xref )."
21463282
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"Voltage-dependent inactivation of TTX-R Na(+) channels in these neurons was shifted to hyperpolarized potentials by 4 mV."
15120592
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"The biophysical origin of such effect is believed to be the differential kinetics of the voltage-dependent activation and inactivation of sodium and potassium channels on the neuron membrane (for further details, see xref )."
21408148
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"The mutations also disabled FHF modulation of voltage-dependent fast inactivation of sodium channels in neuronal cells."
19406745
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"Consequently, the amplitude of APs reduces due to voltage-dependent inactivation of Na v channels."
27044683
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"The FB model anesthetics have qualitatively similar effects on Na v as clinically used halogenated anesthetics such as ISO, sevoflurane, and desflurane, all of which produce voltage-dependent inhibition of Na v function ( xref ; xref ; xref ; xref )."
25385786
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"As expected, DCJW caused a slowly developing, voltage-dependent inhibition of Na v 1.4 current ( xref )."
27993108
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"In accordance with the previous reports, the voltage-dependent activation and inactivation of Na v 1.2α were not affected by the PKA regulation xref , which held to be true for the case of Na v 1.2α co-expression with the β1 subunit as well."
24430351
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"As such, early studies hypothesized that CaM and/or the channel vestigial EF hand segment might modulate particular attributes of Na channel voltage-dependent inactivation [ xref , xref ]."
25966688
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"In the current-clamp mode, constant currents (up to 0.25 nA) were applied to set the resting membrane potential between −90 and −100 mV and thus to remove voltage-dependent inactivation of the sodium [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12941379
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"This nonlinear modulation of BmK AS could also be observed on voltage-dependent fast and slow inactivation of Na v 1.2α, in which the inactivation curves were both negatively shifted by 1 nM or 100 nM BmK AS but not by 10 nM BmK AS."
24430351
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"Cold typically inhibits neuronal excitability, partly by increasing voltage-dependent inactivation of voltage-gated sodium (Nav) channels."
25622298
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"Therefore, the anticonvulsant potentiation observed with the FBM+VPA combination is more likely to be due to the additive effect of the voltage-dependent Na + inhibition of the two drugs than to an i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12798671
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"Loss of Na(V)1.1 did not change voltage-dependent activation or inactivation of sodium channels in hippocampal neurons."
16921370
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"In contrast with activation, the hyperpolarized shift of voltage-dependent inactivation of Na v 1.2α by BmK AS could be reproduced on Na v 1.2 (α + β1)."
24430351
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"These findings suggest that the primary electrophysiological effect of Ro 22-9194 as an antiarrhythmicagent is, like moricizine, a use- and voltage-dependent inhibition of sodium channels."
7712017
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"We further identified that changes in neuronal currents were originated from temperature-induced shifts in voltage-dependent activation and inactivation of Na and K channels."
19034696
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"The time course of recovery from voltage-dependent inactivation of sodium current during conditioned block was both slowed and exhibited voltage dependence."
6319681
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"These data are consistent with a phosphorylation-dependent control of back-propagation during trains of action potentials, attributable mainly to an increase in the time constant of recovery from voltage-dependent inactivation of dendritic Na(+) channels."
21209358
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"Filament breakup was due to SAC recruitment in regions of high fiber stretch (away from the spiral core), resulting in voltage-dependent inactivation of sodium channels there, a mechanism for breakup that is different from other known mechanisms for wavebreak such as restitution (Garfinkel et al., xref )."
21886622
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"These results showed that both mexiletine and lidocaine significantly caused the shift of voltage-dependent inactivation of Na v 1.5 or Na v 1.7 to the hyperpolarized direction, reflecting a shift in equilibrium from resting to inactivated states, and thus providing a basis for suppressing repetitive firing."
26068619
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"The sodium current showed voltage-dependent activation and inactivation."
2445391
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"The voltage-dependent steady-state inactivation of DRG-type sodium channels was determined by eliciting 400-ms conditioning pulses to voltages between −140 and 0 mV in 10 mV increments followed by a 80 ms standard test pulse to 0 mV."
26491429
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"We found that differentiating hiPSC-derived neuronal cells in co-cultures progressively displayed more negative resting membrane potentials to a level sufficient to remove voltage-dependent inactivation of sodium channels and to fire repetitive action potentials."
27819315
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"LQT3 is caused by a gain of function variation in SCN5A, resulting in decreased voltage dependent inactivation of sodium channels."
24632794
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"Voltage-dependent activation and inactivation of Na v 1.4, but not Na v 1.5, shifts when expressed in cells incapable of sialylation, indicating not all VGSCs are affected equally ( xref )."
27252364
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"This was shown to be due to a modulation of the voltage-dependent inactivation of both sodium (INa) and calcium (ICa) currents."
8901621
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"These findings suggest that the primary electrophysiological effect of SD-3212 is a use- and voltage-dependent inhibition of sodium channels."
7881749