IndraLab

Statements


MDM2-Y489A inhibits TP53. 3 / 4
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"In agreement with previous in vitro studies showing that Mdm2 Y489A does not degrade p53, this data demonstrates that endogenous Mdm2 Y487A has similarly lost this function."

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"Both Mdm2 Y489A and Mdmx F488A suppresses p53 transactivation function."

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"By normalizing the amount of p21 mRNA to p53 protein, we found that both Mdm2 Y489A and Mdmx F488A reduce p53 specific activity (XREF_SUPPLEMENTARY)."