IndraLab

Statements

PRKCA activates RAF1. 22 / 26
2 | 3 9 8
signor
"Pkc can effectively phosphorylate raf-1, this is a direct effect of activated pkc and not the result of raf-1 autophosphorylation."
8288587
sparser
"In patients treated with BRAF inhibitors, PKCα-dependent activation of RAF1 provides a means for reactivation of ERK signaling."
30543563
reach
"It has been proposed that the PKC-alpha isoform directly phosphorylates and activates the proto-oncogene Raf-1 to initiate signaling via the MAP kinase cascade [33] and that cell growth is dependent o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10559525
sparser
"PKCα activates RAF1, which in turn activates MEK1, and activates downstream transcriptional targets of MAPK through activation of JNK signaling."
30543563
sparser
"PKCa activates raf-1 by direct phosporylation."
7859227
trips
"PKC alpha directly phosphorylates and activates Raf-1 both in vitro and in vivo."
8321321
reach
"PKCa activates raf-1 by direct phosporylation."
7859227
reach
"Raf-1 is also activated independently of Ras by Bcl-2 and PKC-alpha."
12804699
trips
"Mutation of serine at this position or at residue 259 does not abrogate Raf-1 stimulation by a combination of Ras plus the src tyrosine kinase Lck, but severely impedes Raf-1 activation by PKC alpha."
8321321
sparser
"First, PKCα activates RAF1, which leads to activation of MAPK signaling independent of upstream activation of BRAF and NRAS."
30543563
reach
"An important step for metastasis is that protein kinase C alpha activates RAF-1 by direct phosphorylation [78]."
31731625
signor
"Pkc can effectively phosphorylate raf-1, this is a direct effect of activated pkc and not the result of raf-1 autophosphorylation."
12551925
reach
"PKCalpha activates RAF1, which in turn activates MEK1, and activates downstream transcriptional targets of MAPK through activation of JNK signaling."
30543563
reach
"PKC-alpha can activate Raf-1 by direct phosphorylation leading to the activation of proliferation associated genes via the MAP kinase cascade [6]."
9009219
reach
"For several years, it has been established that PKC-alpha directly phosphorylates and activates the serine/threonine kinase Raf-1 in vitro and in vivo [134]."
10076047
reach
"PKCalpha promotes activation of Raf1 by direct phosphorylation [XREF_BIBR, XREF_BIBR]."
18194572
sparser
"Raf-1 is also activated independently of Ras by Bcl-2 and PKC-α."
12804699
sparser
"It is reported that PKC-alpha can directly phosphorylate or activate Raf-1 in NIH3 T3 cells."
10684111
sparser
"PKC-α can activate Raf-1 by direct phosphorylation leading to the activation of proliferation-associated genes via the MAP kinase cascade [6] ."
9009219
reach
"Conclusion These results indicate that U937 cells under hypoxia induce IL-1b and TNF-a expression and this induction requires PKCa activation, and PKCa-mediated Raf-1/NF-kB pathway."
15569277
sparser
"It is known that PKCα activates c-Raf1, which phosphorylates and activates MEK1, upstream kinase of ERK ( Schönwasser et al , 1998 )."
15102074
trips
"Protein kinase C alpha activates RAF-1 by direct phosphorylation."
8321321