IndraLab

Statements

USP15 inhibits IFNB1. 7 / 7
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"The result showed that USP15 caused the dose dependent inhibition of IFN-beta promoter activity (XREF_FIG)."
26061460
reach
"We found both USP15-HA and USP15-Myc dose-dependently inhibited the SEV- and RIG-I-N-induced activation of IFN-beta."
26061460
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"As observed in HEK293T cells, ectopic expression of USP15 inhibits SEV induced IFN-beta promoter activation, while knockdown of USP15 by siRNA results in upregulation of the activation of IFN-beta, NF-kappaB and IRF3 promoters in A549 cells, as well as the production of IFNB1 and ISGs."
26061460
reach
"Depletion of endogenous USP15 reduced the extent of IFN-beta promoter activation stimulated by GST-RIG-I (2CARD) alone or together with TRIM25 (XREF_FIG)."
24399297
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"In addition, USP15 dose-dependently inhibited RIG-I-N-triggered IFN-beta-Luc, ISRE-Luc, NF-kappaB-Luc, and IRF3-Luc reporter activities."
26061460
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"Cellular ubiquitin-specific proteases, USP21 ( Fan et al., 2014 ), USP3 ( Cui et al., 2014 ) and USP15 ( Zhang et al., 2015 ), a subfamily of deubiqutinase ( Reyes-Turcu et al., 2009 ), remove K63-lin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28286234
reach
"Cellular ubiquitin specific proteases, USP21, USP3 and USP15, a subfamily of deubiqutinase, remove K63 linked polyubiquitin chains from RIG-I and block it to induce IFN-beta."
28286234