IndraLab

Statements

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"In addition, CYLD is known to suppress NASH, reducing lipid accumulation, insulin resistance, inflammation, and fibrosis in mice."
37394587
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"Previous studies indicate that CYLD overexpression reduced inflammation during acute or chronic liver injury."
29163038
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"CYLD reduced SARS-CoV-2 infection by dampening inflammation."
38213785
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"As very recently described, the deubiquitinase Cyld regulates the function of the NLRP6 inflammasome and prevents excessive inflammation via the production of IL-18."
33314083
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"We observed that overexpression of Cyld in hepatocytes concomitantly inhibits lipid accumulation, insulin resistance, inflammation and fibrosis in mice with NASH induced in an experimental setting."
29291351
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"Similar results are seen in vivo; Cyld knockout mice, generated by Zhang et al. [21], were susceptible to induced colonic inflammation by using colitis associated cancer (CAC)."
20347313
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"Previous studies indicate that CYLD overexpression reduces inflammation during acute or chronic liver injury, and during nephropathy ( Hellerbrand & Massoumi 2016, Cui et al. 2009, Nikolaou et al. 201[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32688031
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"As shown in XREF_FIG, PDE4B knockdown selectively inhibited activation of JNK2 but not JNK1, thereby confirming that PDE4B negatively regulates NTHi induced CYLD expression and mediates inflammation via specific activation of JNK2 but not JNK1."
23575688
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"CYLD itself is an inhibitor of inflammation [35]."
| DOI
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"Focusing on recent data concerning the normal functions and signaling interactions of the CYLD gene product, we explain how CYLD interferes with TNF-alpha or TLR mediated signaling as well as with JNK or NF-kappaB-dependent p65/50 signaling to limit inflammation."
18008375
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"We will further pursue studies to determine if the DUB activity of CYLD is required for CYLD-mediated suppression of inflammatory response induced by S. pneumoniae."
31900337
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"In addition, it is also possible that CYLD may inhibit ERK activation and inflammation via up-regulation of MAPK phosphatase-1 (MKP-1)."
31900337
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"CYLD may prevent excessive inflammation due to an antiviral innate immune response by suppressing IKK complex and NF-κB activation downstream of TLR3 in hRPTECs."
39259342
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"However, it should be noted that CYLD negatively regulates NF-κB-dependent inflammation during non-typeable H. influenzae infection and protects mice from deleterious inflammatory responses (65)."
39958342
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"In a similar study, CYLD was shown to negatively regulate NF-kappaB activation and lung inflammation in mice infected with non typeable Haemophilus influenzae 22."
18535581
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"Similarly, CYLD impairs inflammation and protects mice from E. coli-induced pneumonia (35), suggesting that the protective or detrimental function of CYLD in infectious diseases depends on the underlying infection."
39958342
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"CYLD suppresses NF-kappaB-dependent inflammation by removing K63 linked polyubiquitin chains from TRAF2, TRAF6, NEMO, TAK1, Bcl3 and RIP1."
23575688
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"CYLD deficiency triggers a multistep mechanism that mimics the major hallmarks of human HCC: hepatocyte death, inflammation, and fibrosis."
22698400
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"CYLD restricts inflammation by inhibiting NFkappaB activation [XREF_BIBR], yet it can induce innate immune responses by stabilizing STING, a cytosolic DNA sensor and a major regulator of type I interferon signaling, via its deubiquitination on K48 linked chains [XREF_BIBR]."
| PMC
eidos
"CYLD restricts inflammation by inhibiting NFkappaB activation [ 52 ] , yet it can induce innate immune responses by stabilizing STING , a cytosolic DNA sensor and a major regulator of type I interferon signaling , via its deubiquitination on K48-linked chains [ 53 ] ."
| PMC
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"CYLD also inhibited inflammation and proliferation in vascular cells and represented a novel target for the treatment or prevention of atherosclerosis [XREF_BIBR]."
27738385
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"Recent insights into the normal functions and signaling interactions of the CYLD gene product indicate that CYLD interferes with NF-kappaB, JNK, and p38MAPK signaling to limit inflammation and cancer,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20347313
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"In line with the studies described above (134), CYLD knockout caused increased destruction of intestinal epithelia and severe colonic inflammation when challenged by pathological factors."
34956195
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"Deficiency of either Itch or CYLD, essential ubiquitin modulators for TAK1 inactivation, enhances tumor-associated macrophage-induced inflammation, tumorigenesis, and metastasis in a Lewis lung carcin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22795313
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"This is in contrast with dysregulated TNFR1 signaling commonly observed in liver disease and cancer and the fact that liver specific deletion of CYLD induces TNFR1 mediated liver inflammation and development of hepatocellular carcinoma [XREF_BIBR, XREF_BIBR]."
33288901
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"Methods:. Foxp3-restricted CYLD conditional knockout mice (cKO) were examined in mouse models of allergen-induced airway inflammation and Nippostrongylus brasiliensis infection."
33309741
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"CYLD is an inhibitor of inflammation [53]."
34071557
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"Since the majority of correlations were between IA genes and pro-inflammatory pathways and signatures, the dysregulation of CYLD represents an exception, and we hypothesize that CYLD may be expressed as a response to attenuate excessive inflammation."
34071557
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"We also have shown that the deubiquitinase cylindromatosis (CYLD) suppresses NTHi induced inflammation."
25389768
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"Recently, it has been reported that NTHi induces interleukin (IL) -8 expression in an extracellular signal regulated kinase (ERK)-dependent manner.4 Moreover, it also has been shown that CYLD suppresses NTHi induced inflammation."
30628115
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"Spontaneous lung inflammation caused by the CYLD cKO deficiency was also ameliorated by Scinderin deletion (Fig 6, F and G)."
33309741
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"By negatively regulating NF-κB activation, CYLD limits the inflammatory response during infections, thus minimizing tissue damage [26–28] ."
28082198
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"Specific deletion of CYLD in Foxp3 Treg cells caused inflammation in the lungs correlating with their increased migratory activity into the lungs."
33309741
eidos
"Similarly , deficiency in CYLD or A20 , a master regulator of NFkappaB , lead to overt pathway activation and inflammation ( 132 ) ."
33324551
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"In the present study, we identified PDE4B as a key negative regulator for CYLD via selective activation of c-jun N-terminal kinase 2 (JNK2), but not JNK1, and inhibition of PDE4B significantly enhanced NTHi induced CYLD expression and suppressed inflammation."
23575688
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"Oxidation can also inhibit the catalytic activity of CYLD (Wang and Wang, 2021), meaning that disruption of CYLD through oxidative stress could enhance inflammation."
37387450
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"Although additional studies are needed to clarify the molecular mechanisms, our in vitro data suggested that hypoxia induced CYLD reduction may promote inflammation in an autocrine and paracrine fashion in GBM tissues."
25071012
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"CYLD, another USP, restricts IBD inflammation in the colonic mucosa by inhibiting excessive production of IL-18 through deubiquitinating NLRP6 (70)."
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"For example, CYLD has been shown to downregulate the inflammatory response following bacterial infection with Escherichia coli by negatively regulating the innate immune response via inhibition of NF-kappaB signalling."
22730341
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"Reduced expression of CYLD promotes cell survival and inflammation in gefitinib treated NSCLC PC-9 cells : targeting CYLD may be beneficial for acquired resistance to gefitinib therapy."
32441799
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"The mechanism about down-regulation of CYLD in the hepatocyte nucleus of HBV-ACLF patients will be our future research direction.Previous studies indicated that CYLD regulates chemokine production [42,47], and down-regulated CYLD leads to up-regulation of CCL2 and IL-8 production and exacerbates inflammatory response [42]."
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