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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Kinase-active RPS6KB1 activates RPS6. 1 / 1

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"Activation of S6K1 also occurs within minutes of initiation of signalling through mTOR. S6K1 phosphorylates ribosomal protein S6, which reportedly enhances the translation of mRNA with an uninterrupted string of pyrimidine residues adjacent to the 5k-cap structure (terminal oligopyrimidine mRNA; Meyuhas, 2000). Proteins encoded by such mRNA include ribosomal proteins, translation elongation factors and poly(A) binding protein. Thus, activation of S6K1 results in a rapid increase in the synthesis of a subset of proteins."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...