IndraLab

Statements

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"USP19 was shown to inhibit cell proliferation, while inducing apoptosis by reducing ubiquitination and degradation of BAG6 and enhancing BCL2 induced ER stress by elevating the intracellular Ca concentration."
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"Depletion of USP19 inhibited proliferation in prostate cancer DU145, PC-3 and 22RV1 cells, which was similar to the pattern established in fibroblasts in that it was due to decreased progression from G1 to S phase and associated with a stabilization of the cyclin-dependent kinase inhibitor p27 Kip1 ."
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"Depletion of USP19 inhibited proliferation in prostate cancer DU145, PC-3 and 22RV1 cells, which was similar to the pattern established in fibroblasts in that it was due to decreased progression from G1 to S phase and associated with a stabilization of the cyclin dependent kinase inhibitor p27 Kip1."
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"USP19 deubiquitinates and thereby stabilizes the KPC1 ligase for p27 Kip1, and so indirectly promotes degradation of p27 Kip1 and subsequent cell proliferation."
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"We also found that USP19 overexpression inhibits cell proliferation, induces apoptosis, and regulates cell‐cycle assay in TNBC cells."
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"USP19 was significantly regulated in MDA‐MB‐231 compared with the levels detected in the control groups (Figure S1F).3.2 USP19 suppressed cell proliferation and induced apoptosis of BC cell lines."
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"Opposite to our findings, Hu and collaborators recently demonstrated that USP19 negatively regulates proliferation and migration in clear cell renal carcinoma 69."
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"We demonstrated that expression of USP19 inhibited proliferation and induced apoptosis in TNBC cells, as well as promoting BAG6 protein expression by deubiquitinating modification."
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