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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

NFkappaB decreases the amount of IRS1. 2 / 2

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"NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells), one of the important inflammatory pathways, can decrease the expression of insulin receptor substrate 1 (IRS1) in patients with IR [XREF_BIBR]."

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"As the important target of the inflammatory pathways, NF-kappaB could disrupt IRS1 and downregulate the expression of IRS1 under conditions of insulin resistance [XREF_BIBR, XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...