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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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MTOR leads to the phosphorylation of mutated EIF4EBP1. 3 / 3

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"In addition, the inducible expression of a mutant 4E-BP1 protein that can not be phosphorylated by mTOR blocked protein synthesis and inhibited the growth of Ewing sarcoma cells in vitro and in vivo in a xenograft."

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"We also engineered a mutant 4E-BP1 that can not be phosphorylated by mTOR resembling de-phospho-Thr46-4E-BP1, and generated HNSCC cells expressing this mutant in a tetracycline inducible fashion."

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"MTORi treatment or conditional expression of a mutant 4E-BP1 that can not be phosphorylated by mTOR was sufficient to disrupt the translation initiation complex and prevent tumor growth."

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MTOR leads to the phosphorylation of mutated EIF4EBP1. 3 / 3

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