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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

TP53 bound to MDM2 decreases the amount of TP53. 3 / 3
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"In recent studies, we found that treatment with nutlin-3a, an inhibitor of the interaction between p53 and the ubiquitin ligase Mdm2, markedly increased lung p53 levels and protected against PH by inducing PA-SMC senescence."
"The N-terminal hydrophobic pocket of Mdm2 binds to p53 and thereby inhibits the transcription of p53 target genes."
"Via disruption of the MDM2 and p53 complex, nutlin-3 effectively induced p53 levels in a panel of cancer cell lines carrying wild-type p53, resulting in apoptosis or cell cycle arrest in vitro as well as in vivo."