IndraLab

Statements


TP53 bound to MDM2 decreases the amount of TP53. 4 / 4
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"Via disruption of the MDM2 and p53 complex, nutlin-3 effectively induced p53 levels in a panel of cancer cell lines carrying wild-type p53, resulting in apoptosis or cell cycle arrest in vitro as well as in vivo."

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"In recent studies, we found that treatment with nutlin-3a, an inhibitor of the interaction between p53 and the ubiquitin ligase Mdm2, markedly increased lung p53 levels and protected against PH by inducing PA-SMC senescence."

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"The N-terminal hydrophobic pocket of Mdm2 binds to p53 and thereby inhibits the transcription of p53 target genes."

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"Blockade of interaction between p53 and MDM2 by the binding inhibitor nutlin-3a induced p73 expression in p53 mutant PC-9/G cells, and p53 expression in p53 wild-type HCC827-OR cells, respectively (XREF_SUPPLEMENTARY)."