IndraLab

Statements

PRKN activates USP30. 3 / 3
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"Whilst the phosphatase that dephosphorylates p-Ub remains unknown, two DUBs have been identified that deubiquitylate Parkin directed substrates, USP30 and USP15, and USP8 has also been reported to reverse Parkin autoubiquitylation."
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"This may suggest that USP35 plays additional roles in the cytosol to delay PARK2 mediated mitophagy.Overexpressing USP30 but not USP35 delays PARK2 recruitmentIn cells with a healthy mitochondrial network, PARK2 is diffused in the cytosol and not on mitochondria.9 However, following mitophagy activation by CCCP treatment, PARK2 is recruited to mitochondria within 1 h."
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"Although SILAC provides a rigorous way for performing quantification, other studies used label-free quantification to examine targeted mitochondrial outer membrane ubiquitylation by PARKIN in the presence or absence of the mitochondrial deubiquitylating enzyme USP30, leading to the identification of a dozen mitochondrial PARKIN targets that are regulated by USP30 (see below)."
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